צרבונין 120 מ"ג (EGb 761)צרבונין 120 מ"ג (EGb 761)
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צרבונין 120 מ"ג (EGb 761)
  • דף הבית
  • עדכונים »
    • Cognitive decline
    • Dementia
  • מידע מקצועי »
    • דף מידע
    • ברושור
    • צרבונין – מנגנון פעולה
    • עלון לרופא
    • עלון לצרכן
    • וובינר מוקלט – ניהול הפרעות קוגניטיביות בגיל המבוגר
    • מצגת
    • Cerebonin® 120mg – first line treatment for cognitive decline
    • Cerebonin® 120mg – An anti-dementia drug that goes beyond cognition
  • צור קשר
  • פרטי החברה
  • דף הבית
  • עדכונים
    • Cognitive decline
    • Dementia
  • מידע מקצועי
    • דף מידע
    • ברושור
    • צרבונין – מנגנון פעולה
    • עלון לרופא
    • עלון לצרכן
    • וובינר מוקלט – ניהול הפרעות קוגניטיביות בגיל המבוגר
    • מצגת
    • Cerebonin® 120mg – first line treatment for cognitive decline
    • Cerebonin® 120mg – An anti-dementia drug that goes beyond cognition
  • צור קשר
  • פרטי החברה

Efficacy and safety of Ginkgo biloba extract EGb 761® in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multicenter trial

'מערכת אימד' 14/10/2014 13:39 אין תגובות

Geriatric Psychiatry

Research Article

I. Gavrilova1, U.W. Preuss2, J.W. M. Wong2, R. Hoerr3, R. Kaschel4, N. Bachinskaya5 and the GIMCIPlus Study

Group†
1. Mental Health Research Center of the Russian Academy of Medical Sciences, Moscow, Russia
2. Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital Prignitz, Perleberg, Germany
3. Clinical Research Department, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany
4. Department of Psychology, University of Osnabrück, Osnabrück, Germany
5. Institute of Gerontology, Academy of Medical Sciences, Kiev, Ukraine

המחקר נערך במטרה להעריך את יעילות ובטיחות הטיפול בתמצית גינקו בילובה מסוג EGb 761® על תפקוד קוגניטיבי בחולים עם ירידה קוגניטיבית קלה (MCI ) המלווה בתסמינים התנהגותיים.

במחקר הוכללו 160 מטופלים המאובחנים עם MCI ותסמינים התנהגותיים. המחקר היה רב- מרכזי, כפול סמיות ובהשוואה לפלסבו. הנבדקים טופלו ב- EGb 761® במינון 240 מ"ג ליום או בפלסבו, במשך 24 שבועות.

השפעות EGb 761® בהיבט הקוגניטיבי הוערכו באמצעות:

  • Trail making test (A/B)
  • Global ratings of change

השפעות EGb 761® בהיבט ההתנהגותי הוערכו באמצעות:

  • מדד NPI
  • State-Trait Anxiety Inventory
  • Geriatric Depression Scale

תוצאות המחקר:

  • בהיבט הקוגניטיבי:
    על פי תוצאות שני מבחני ה-Trail making test, הטיפול ב- EGb 761® נמצא טוב יותר מהטיפול בפלסבו.
  • בהיבט ההתנהגותי:
    • NPI composite score להערכת תסמינים התנהגותיים, פחת ב-7 נקודות בקבוצת הטיפול ב-EGb 761® (p = 0.001)
    • שיפור של 4 נקודות לפחות ב-NPI, נצפה בקרב 78.8% מהחולים שטופלו ב– EGb 761®, לעומת 55.7% מהחולים שטופלו בפלסבו (p = 0.002)
    • עליונות הטיפול ב-EGb 761® בהשוואה לפלסבו נמצאה גם במדד ה-State-Trait Anxiety Inventory.
    • בסולם Geriatric depression התוצאות היו לטובת קבוצת הטיפול ב-EGb 761®.
  • בהיבט הבטיחותי:
    תופעות הלוואי שנצפו במחקר היו כולן לא חמורות ודווחו ע"י 37 חולים מקבוצת הטיפול ב-EGb 761®, לעומת 36 חולים מקבוצת הפלסבו.

Int J Geriatr Psychiatry 2014; 29: 1087–1095

מסקנות המחקר:

  • צרבונין (EGb 761®) משפרת את התפקוד הקוגניטיבי וההתנהגותי במטופלים עם MCI המציגים גם תסמינים התנהגותיים.
  • צרבונין (EGb 761®) היא תרופה בטוחה ונסבלת היטב.

 

קישור למאמר:

Gavrilova et al. Int J Geriatr Psychiatry 2014; 29: 1087–1095

For complete prescribing information please refer to Cerebonin® 120mg –
Physician prescribing information approved by the Ministry of Health on March 2016

Cerebonin_Gavrilova_tsv_0121

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כניסת צוות רפואי

הכניסה לאתר מותרת אך ורק לצוות רפואי
לכניסה נא הזן את פרטי דוא"ל וסיסמתך באתר e-Med :

אינך מנוי/ה? להרשמה לאתר e-Med לחץ כאן

המידע אינו מחליף את המידע המאושר בעלון לרופא ובעלון לצרכן המאושרים ע"י משרד הבריאות