'מערכת אימד'
Gideon Koren, Rana Cohen, Adelson School of Medicine, Ariel University and Motherisk Israel Program
Question:
The delayed release of doxylamine/ pyridoxine (Diclegis®) works well in many of my patients with morning sickness. The problem I have is that it takes several hours to begin to work. Is there anything that can overcome this problem?
Answer:
Due to its delayed release properties, Diclegis® begins to exert its antiemetic properties 6-8 hours after ingestion, and hence symptom relief may be delayed and necessitate the use of an immediate release medication. In 2016 the FDA approved Bonjesta®, a novel, dual- release combination of doxylamine and pyridoxine, whereby a rapid release phase is followed by the delayed release drug, thus overcoming the time delay in action of Diclegis® .
Motherisk Intl J 2020;1;19