{"id":276,"date":"2024-09-09T14:35:45","date_gmt":"2024-09-09T11:35:45","guid":{"rendered":"https:\/\/info.e-med.co.il\/veoza\/?page_id=276"},"modified":"2024-09-16T09:52:20","modified_gmt":"2024-09-16T06:52:20","slug":"efficacy-and-safety","status":"publish","type":"page","link":"https:\/\/info.e-med.co.il\/veoza\/efficacy-and-safety\/","title":{"rendered":"Efficacy and Safety"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"276\" class=\"elementor elementor-276\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c471da1 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c471da1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e4dd1f\" data-id=\"5e4dd1f\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c1acd35 elementor-widget elementor-widget-image\" data-id=\"c1acd35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"479\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-efficacy-and-safety-1024x479.jpg\" class=\"attachment-large size-large wp-image-191\" alt=\"Ready, Aim, Relief\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-efficacy-and-safety-1024x479.jpg 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-efficacy-and-safety-300x140.jpg 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-efficacy-and-safety-768x359.jpg 768w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-efficacy-and-safety.jpg 1276w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ea3fc91 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"ea3fc91\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-11d2c47\" data-id=\"11d2c47\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a7b64b0 elementor-widget elementor-widget-heading\" data-id=\"a7b64b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">VEOZA achieved clinically meaningful VMS reductions and was evaluated for safety for up to a year<sup>1<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-260ae1a elementor-widget elementor-widget-heading\" data-id=\"260ae1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Study Design<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb3fa12 elementor-widget elementor-widget-text-editor\" data-id=\"bb3fa12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The efficacy of VEOZA was evaluated in two 12-week, randomised, placebo-controlled, double-blind Phase 3 studies, followed by a 40-week uncontrolled extension treatment period<sup>1<\/sup><\/p><p>Coprimary endpoints: Mean change from baseline in moderate to severe VMS frequency and severity<sup>1<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfde890 elementor-widget elementor-widget-text-editor\" data-id=\"cfde890\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>*Clinically meaningful is defined as a reduction in \u22652 hot flushes per day versus placebo.<sup>1<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f1bfc56 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f1bfc56\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-553c7d3\" data-id=\"553c7d3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c48a14e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c48a14e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-d105cbe\" data-id=\"d105cbe\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d8d774 elementor-tablet-align-justify elementor-align-center elementor-widget elementor-widget-button\" data-id=\"7d8d774\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjI4NyIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study Population<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-fdd1e57\" data-id=\"fdd1e57\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b11b4b9 elementor-tablet-align-justify elementor-align-center elementor-widget elementor-widget-button\" data-id=\"b11b4b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjMwMCIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\"> Inclusion Criteria<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-959fa2d\" data-id=\"959fa2d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f472227 elementor-tablet-align-justify elementor-align-center elementor-widget elementor-widget-button\" data-id=\"f472227\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjMwNiIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\"> Exclusion Criteria<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-69d6389 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"69d6389\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a0b7c4e\" data-id=\"a0b7c4e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ade7cfe elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"ade7cfe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-bd223d9\" data-id=\"bd223d9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b67fa47 elementor-widget elementor-widget-heading\" data-id=\"b67fa47\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Achieve fewer and less severe VMS episodes with VEOZA<sup>1<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6e7d6a elementor-widget elementor-widget-text-editor\" data-id=\"f6e7d6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>VEOZA provides statistically significant relief from the number and severity of daily hot flushes and night sweats<sup>1<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d67407 elementor-widget elementor-widget-text-editor\" data-id=\"7d67407\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>FREQUENCY: Measured as a daily mean and analyzed as weekly average.<sup>1<\/sup><\/p><p>LS mean: Least squares mean estimated from a mixed model for repeated measures analysis of covariance.<sup>1<\/sup><\/p><p><sup>\u2020<\/sup>Statistically significantly superior compared to placebo at the 0.05 level with multiplicity adjustment.<sup>1<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-35ea9e2\" data-id=\"35ea9e2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aba3322 elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"aba3322\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"502\" height=\"424\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-efficacy-3.png\" class=\"attachment-large size-large wp-image-240\" alt=\"Achieve fewer and less severe VMS episodes with VEOZA\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-efficacy-3.png 502w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-efficacy-3-300x253.png 300w\" sizes=\"(max-width: 502px) 100vw, 502px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f278dd elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"8f278dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"573\" height=\"1024\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile1-v1-1-573x1024.png\" class=\"attachment-large size-large wp-image-421\" alt=\"Achieve fewer and less severe VMS episodes with VEOZA\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile1-v1-1-573x1024.png 573w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile1-v1-1-168x300.png 168w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile1-v1-1.png 600w\" sizes=\"(max-width: 573px) 100vw, 573px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23f45f6 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"23f45f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"573\" height=\"1024\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile2-v1-1-573x1024.png\" class=\"attachment-large size-large wp-image-419\" alt=\"Achieve fewer and less severe VMS episodes with VEOZA\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile2-v1-1-573x1024.png 573w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile2-v1-1-168x300.png 168w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-en-efficacy-image1-mobile2-v1-1.png 600w\" sizes=\"(max-width: 573px) 100vw, 573px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-799c9fc elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"799c9fc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6499ad5\" data-id=\"6499ad5\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b837514 elementor-section-full_width elementor-reverse-tablet elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"b837514\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-28ca7e5\" data-id=\"28ca7e5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f500c51 elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"f500c51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"496\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-efficacy-safety-1-3.png\" class=\"attachment-large size-large wp-image-315\" alt=\"Reduction in severity of VMS episodes\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-efficacy-safety-1-3.png 900w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-efficacy-safety-1-3-300x165.png 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-efficacy-safety-1-3-768x423.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b14de6 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"6b14de6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"279\" height=\"1024\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/efficacy-and-safety-frequency-mobile-vms-279x1024.png\" class=\"attachment-large size-large wp-image-420\" alt=\"Reduction in severity of VMS episodes\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/efficacy-and-safety-frequency-mobile-vms-279x1024.png 279w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/efficacy-and-safety-frequency-mobile-vms-82x300.png 82w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/efficacy-and-safety-frequency-mobile-vms.png 360w\" sizes=\"(max-width: 279px) 100vw, 279px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-3c8fc3c\" data-id=\"3c8fc3c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bc2e21 elementor-widget elementor-widget-heading\" data-id=\"8bc2e21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Reduction in severity of VMS episodes<sup>1<\/sup><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-553853c elementor-widget elementor-widget-text-editor\" data-id=\"553853c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tVEOZA provided statistically significant reductions in the severity of VMS episodes at weeks 4 and 12<sup>1<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5080e31 elementor-widget elementor-widget-text-editor\" data-id=\"5080e31\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>BLN: Baseline.<br \/><br \/>Data contain a pooled analysis of Skylight 1 and 2.<br \/><br \/><sup>\u2021<\/sup>Statistically significantly superior compared to placebo at the 0.05 level with multiplicity adjustment.<sup>1<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db20ac4 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"db20ac4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b5140b8\" data-id=\"b5140b8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-db55838 elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"db55838\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/thumbs\/patients-continue-activity-qtwdnx7u8cc9a72xj5fyiqdgj8lfm8m6aj00b4y0z4.png\" title=\"patients-continue-activity\" alt=\"patients-continue-activity\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Now there\u2019s VEOZA, with results to help your patients continue activity with less sweat and disruption<sup>1,3,4<\/sup><\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f37053d elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"f37053d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-128bc30\" data-id=\"128bc30\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d71ed46 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d71ed46\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-b4cab8e\" data-id=\"b4cab8e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dff7e17 elementor-widget elementor-widget-heading\" data-id=\"dff7e17\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Relief that works fast and lasts<sup>3,4<\/sup><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4b42db elementor-widget elementor-widget-text-editor\" data-id=\"b4b42db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tIn 1 week, patients taking VEOZA experienced a reduction in the number of VMS episodes, which was sustained through 52 weeks<sup>3,4<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bbbdd3a elementor-widget elementor-widget-text-editor\" data-id=\"bbbdd3a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mean change in frequency of VMS from baseline to each week up to week 12 was a secondary endpoint and was not adjusted for multiplicity.<sup>3,4<\/sup><\/p><p>Mean change in the frequency of VMS from baseline to each visit in the extension period was an exploratory endpoint. Assessments after the 12-week placebo-controlled period were descriptive only.<sup>4,5<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-efb99a5\" data-id=\"efb99a5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-02617ab elementor-widget elementor-widget-image\" data-id=\"02617ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"506\" height=\"323\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-veoza-img-4-1.png\" class=\"attachment-large size-large wp-image-324\" alt=\"\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-veoza-img-4-1.png 506w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-veoza-img-4-1-300x192.png 300w\" sizes=\"(max-width: 506px) 100vw, 506px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b96d0f6 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"b96d0f6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8527edb\" data-id=\"8527edb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e9bd9fc elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"e9bd9fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2451\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2451\" aria-expanded=\"false\">Nighttime<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2452\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2452\" aria-expanded=\"false\">Daytime<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2451\" aria-expanded=\"false\">Nighttime<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2451\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2451\" tabindex=\"0\" hidden=\"false\"><p><a href=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-192\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot1.jpg\" alt=\"Veoza nighttime\" width=\"1200\" height=\"712\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot1.jpg 1200w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot1-300x178.jpg 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot1-1024x608.jpg 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot1-768x456.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/a><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2452\" aria-expanded=\"false\">Daytime<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2452\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2452\" tabindex=\"0\" hidden=\"hidden\"><p><a href=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-193\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot2.jpg\" alt=\"Veoza daytime\" width=\"1200\" height=\"712\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot2.jpg 1200w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot2-300x178.jpg 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot2-1024x608.jpg 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-veoza-slot2-768x456.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/a><\/p><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c4fa9a3 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"c4fa9a3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a18b785\" data-id=\"a18b785\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f2a0292 elementor-widget elementor-widget-heading\" data-id=\"f2a0292\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">VEOZA was studied for safety and tolerability for 1 year<sup>1<\/sup><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d00206d elementor-widget elementor-widget-text-editor\" data-id=\"d00206d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe safety of VEOZA was evaluated in Phase 3 clinical studies with 2203 women receiving VEOZA<sup>1<\/sup>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-17cc561 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"17cc561\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-516d54f\" data-id=\"516d54f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-49def43 elementor-widget elementor-widget-heading\" data-id=\"49def43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Skylight 1 &amp; 2<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-428863c elementor-widget elementor-widget-text-editor\" data-id=\"428863c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tTwo identical Phase 3 efficacy and safety studies that were randomised, placebo-controlled, double-blind for 12 weeks, followed by rerandomisation of women previously receiving placebo to VEOZA (women on VEOZA remained on VEOZA) for an additional 40 weeks of uncontrolled treatment\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1aaf6d5\" data-id=\"1aaf6d5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c33983 elementor-widget elementor-widget-heading\" data-id=\"7c33983\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Skylight 4<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0cc4f2d elementor-widget elementor-widget-text-editor\" data-id=\"0cc4f2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tOne Phase 3, 52-week, randomised, placebo-controlled, double-blind study evaluating safety\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3ec25bd elementor-section-full_width elementor-section-content-middle elementor-section-height-default elementor-section-height-default\" data-id=\"3ec25bd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-298001a\" data-id=\"298001a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2a0ea87 elementor-widget elementor-widget-heading\" data-id=\"2a0ea87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Adverse reactions for VEOZA 45 mg<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36c1bf7 elementor-widget elementor-widget-image\" data-id=\"36c1bf7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"526\" height=\"367\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-il-en-adverse-image.png\" class=\"attachment-large size-large wp-image-238\" alt=\"Adverse reactions for VEOZA 45 mg\u200b\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-il-en-adverse-image.png 526w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-il-en-adverse-image-300x209.png 300w\" sizes=\"(max-width: 526px) 100vw, 526px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-47177d3\" data-id=\"47177d3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2394584 elementor-widget elementor-widget-text-editor\" data-id=\"2394584\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Across the Phase 3 studies, the most common adverse reactions (\u22653%) with VEOZA 45 mg were diarrhoea (3.2%) and insomnia (3.0%). The most frequent adverse reactions leading to dose discontinuation with VEOZA were alanine aminotransferase (ALT) increased (0.3%) and insomnia (0.2%)<br \/><br \/><\/li><li>There were no serious adverse reactions reported at an incidence greater than 1% across the total study population<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-84b40ef elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"84b40ef\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cc33f59\" data-id=\"cc33f59\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd3c1c7 elementor-widget elementor-widget-heading\" data-id=\"fd3c1c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">VEOZA was assessed for endometrial safety<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7b26f46 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7b26f46\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6ab90d4\" data-id=\"6ab90d4\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4dc75dd elementor-widget elementor-widget-heading\" data-id=\"4dc75dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">In the long-term safety data, VEOZA was evaluated for tolerability and endometrial safety compared to placebo over 52 weeks<sup>1<\/sup><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-071a849 elementor-widget elementor-widget-text-editor\" data-id=\"071a849\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>1 case of endometrial adenocarcinoma was observed<\/li><li>Endometrial biopsy assessments did not identify an increased risk of endometrial hyperplasia or malignancy according to prespecified criteria for endometrial safety<\/li><li>Transvaginal ultrasound did not reveal increased endometrial thickness<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6f8a200 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6f8a200\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-77ab877\" data-id=\"77ab877\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c16e9fb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c16e9fb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-2be9193\" data-id=\"2be9193\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-95214ef elementor-tablet-align-justify elementor-align-center elementor-widget elementor-widget-button\" data-id=\"95214ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjM2NyIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Study Design<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-531767d\" data-id=\"531767d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fcdebe7 elementor-tablet-align-justify elementor-align-center elementor-widget elementor-widget-button\" data-id=\"fcdebe7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjM3MCIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\"> Inclusion Criteria<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-413ddfd\" data-id=\"413ddfd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-22a0b33 elementor-tablet-align-justify elementor-align-center elementor-widget elementor-widget-button\" data-id=\"22a0b33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjM3NiIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\"> Exclusion Criteria<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7245939 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7245939\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-379d3f0\" data-id=\"379d3f0\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4530e80 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"4530e80\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-b3405d8\" data-id=\"b3405d8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6da5753 elementor-widget elementor-widget-heading\" data-id=\"6da5753\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Learn about VEOZA dosing and administration<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-e470d67 elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"e470d67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"\/veoza\/dosing\/\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-arrow-right\"><\/i>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b0b26a5 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"b0b26a5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29dfa8e\" data-id=\"29dfa8e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e14292f elementor-widget elementor-widget-text-editor\" data-id=\"e14292f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>REFERENCES<\/b>:\u00a0<b>1<\/b>. VEOZA <a href=\"\/veoza\/files\/2024\/09\/veoza-fezolinetant-smpc.pdf\" target=\"_blank\" rel=\"noopener\">[Veoza Israeli SmPC]<\/a> <b>2.<\/b>\u00a0Thurston RC. Vasomotor symptoms. In: Crandall CJ, Bachman GA, Faubion SS, et al., eds. Menopause Practice: A Clinician\u2019s Guide. 6th ed. Pepper Pike, OH: The North American Menopause Society, 2019:43-55.<b>\u00a03.<\/b>\u00a0Lederman S, Ottery FD, Cano A, et al. Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study. Lancet 2023;401(10382):1091-102.\u00a0<b>4.<\/b>\u00a0Johnson KA, Martin N, Nappi RE, et al. Efficacy and safety of fezolinetant in moderate to severe vasomotor symptoms associated with menopause: a phase 3 RCT. J Clin Endocrinol Metab (Epub) 02-03-2023.\u00a0<b>5.<\/b>\u00a0Astellas. VEOZA. Data on file.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>VEOZA achieved clinically meaningful VMS reductions and was evaluated for safety for up to a year1 Study Design The efficacy of VEOZA was evaluated in two 12-week, randomised, placebo-controlled, double-blind Phase 3 studies, followed by a 40-week uncontrolled extension treatment period1 Coprimary endpoints: Mean change from baseline in moderate to severe VMS frequency and severity1 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-276","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"VEOZA achieved clinically meaningful VMS reductions and was evaluated for safety for up to a year1 Study Design The efficacy of VEOZA was evaluated in two 12-week, randomised, placebo-controlled, double-blind Phase 3 studies, followed by a 40-week uncontrolled extension treatment period1Coprimary endpoints: Mean change from baseline in moderate to severe VMS frequency and severity1 *Clinically\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/info.e-med.co.il\/veoza\/efficacy-and-safety\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_GB\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Veoza - 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