{"id":186,"date":"2024-09-08T15:43:39","date_gmt":"2024-09-08T12:43:39","guid":{"rendered":"https:\/\/info.e-med.co.il\/veoza\/?page_id=186"},"modified":"2024-09-16T09:39:30","modified_gmt":"2024-09-16T06:39:30","slug":"mechanism-of-action","status":"publish","type":"page","link":"https:\/\/info.e-med.co.il\/veoza\/mechanism-of-action\/","title":{"rendered":"Mechanism of Action"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"186\" class=\"elementor elementor-186\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c471da1 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c471da1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e4dd1f\" data-id=\"5e4dd1f\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c1acd35 elementor-widget elementor-widget-image\" data-id=\"c1acd35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"479\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-max-mechanism-of-action-1024x479.jpg\" class=\"attachment-large size-large wp-image-194\" alt=\"Redefine how you target VMS\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-max-mechanism-of-action-1024x479.jpg 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-max-mechanism-of-action-300x140.jpg 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-max-mechanism-of-action-768x359.jpg 768w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-il-en-max-mechanism-of-action.jpg 1276w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25e9c39 elementor-widget elementor-widget-menu-anchor\" data-id=\"25e9c39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"veoza-hormone\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c44e49 elementor-section-height-min-height elementor-reverse-tablet elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7c44e49\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-8ea30a1\" data-id=\"8ea30a1\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25ec62c elementor-widget elementor-widget-heading\" data-id=\"25ec62c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">VEOZA is not a hormone.<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f72dfd elementor-widget elementor-widget-heading\" data-id=\"6f72dfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">It\u2019s a first-in-class selective NK3 receptor antagonist that directly blocks NKB, a known trigger of VMS, from binding on the KNDy neuron<sup>1,3,4<\/sup><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4bae5ff elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4bae5ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76cca13 elementor-widget elementor-widget-heading\" data-id=\"76cca13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">KNDy: kisspeptin\/neurokinin B\/dynorphin, NK3: neurokinin 3, NKB: neurokinin B.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-31283d2\" data-id=\"31283d2\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-db9dd6c elementor-widget elementor-widget-image\" data-id=\"db9dd6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"184\" height=\"319\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-is-not-hormone-updated-4.png\" class=\"attachment-full size-full wp-image-195\" alt=\"Block the binding of NKB\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-is-not-hormone-updated-4.png 184w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-is-not-hormone-updated-4-173x300.png 173w\" sizes=\"(max-width: 184px) 100vw, 184px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ea3fc91 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"ea3fc91\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-11d2c47\" data-id=\"11d2c47\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f38bf65 elementor-widget elementor-widget-menu-anchor\" data-id=\"f38bf65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"MOA\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7b64b0 elementor-widget elementor-widget-heading\" data-id=\"a7b64b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Watch the MOA of VEOZA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb41842 elementor-widget elementor-widget-video\" data-id=\"cb41842\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"embed\"><iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/994734185?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-808cdbf elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"808cdbf\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wide\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-e6c95ca\" data-id=\"e6c95ca\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9554b6f elementor-widget elementor-widget-image\" data-id=\"9554b6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-homeostasis-4-1024x768.jpg\" class=\"attachment-large size-large wp-image-235\" alt=\"Homeostasis\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-homeostasis-4-1024x768.jpg 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-homeostasis-4-300x225.jpg 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-homeostasis-4-768x576.jpg 768w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/veoza-hcp-global-en-homeostasis-4.jpg 1056w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc2d554 elementor-widget elementor-widget-heading\" data-id=\"bc2d554\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Homeostasis<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6890e32 elementor-widget elementor-widget-text-editor\" data-id=\"6890e32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>KNDy neurons in the hypothalamus are inhibited by oestrogen and stimulated by the neuropeptide NKB. This balance contributes to<b>\u00a0body temperature regulation<sup>3<\/sup><\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a42e355\" data-id=\"a42e355\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4c055bc elementor-widget elementor-widget-image\" data-id=\"4c055bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/menopause-5-1024x768.jpg\" class=\"attachment-large size-large wp-image-233\" alt=\"Menopause\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/menopause-5-1024x768.jpg 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/menopause-5-300x225.jpg 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/menopause-5-768x576.jpg 768w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/menopause-5.jpg 1408w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca39464 elementor-widget elementor-widget-heading\" data-id=\"ca39464\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Menopause<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3d7288 elementor-widget elementor-widget-text-editor\" data-id=\"c3d7288\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Oestrogen decline during the menopause transition disrupts this balance with NKB.\u00a0<b>Unopposed, NKB signalling causes<\/b>\u00a0heightened KNDy neuronal activity.3 This triggers heat dissipation mechanisms, including vasodilation and sweating\u2014VMS<sup>3<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-99d0fd2\" data-id=\"99d0fd2\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-62ce325 elementor-widget elementor-widget-image\" data-id=\"62ce325\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/blocking-nkb-to-reduce-heat-4-1024x768.jpg\" class=\"attachment-large size-large wp-image-234\" alt=\"Blocking nkb to reduce heat\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/blocking-nkb-to-reduce-heat-4-1024x768.jpg 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/blocking-nkb-to-reduce-heat-4-300x225.jpg 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/blocking-nkb-to-reduce-heat-4-768x576.jpg 768w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/blocking-nkb-to-reduce-heat-4.jpg 1408w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2c0747 elementor-widget elementor-widget-heading\" data-id=\"c2c0747\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Blocking NKB to reduce heat<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2152c10 elementor-widget elementor-widget-text-editor\" data-id=\"2152c10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>VEOZA selectively binds to the NK3 receptor to\u00a0<b>block NKB<\/b>. This action reduces heat signalling between the temperature control centre and the body to help control hot flushes and night sweats<sup>1<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-36ba715 elementor-section-full_width elementor-hidden-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"36ba715\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d28e349\" data-id=\"d28e349\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64e3067 elementor-widget elementor-widget-image\" data-id=\"64e3067\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"108\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-4-1024x108.png\" class=\"attachment-large size-large wp-image-243\" alt=\"MOA\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-4-1024x108.png 1024w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-4-300x32.png 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-4-768x81.png 768w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-4-1536x162.png 1536w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-4.png 1896w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f099848 elementor-section-full_width elementor-hidden-desktop elementor-hidden-tablet elementor-section-height-default elementor-section-height-default\" data-id=\"f099848\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f805c76\" data-id=\"f805c76\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d68a59b elementor-widget elementor-widget-image\" data-id=\"d68a59b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"762\" height=\"573\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/not-a-hormone-2-1.png\" class=\"attachment-large size-large wp-image-242\" alt=\"\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/not-a-hormone-2-1.png 762w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/not-a-hormone-2-1-300x226.png 300w\" sizes=\"(max-width: 762px) 100vw, 762px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-69d6389 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"69d6389\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a0b7c4e\" data-id=\"a0b7c4e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ade7cfe elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"ade7cfe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-35ea9e2\" data-id=\"35ea9e2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aba3322 elementor-widget elementor-widget-image\" data-id=\"aba3322\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1020\" height=\"690\" src=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-of-veoza-flashcard.png\" class=\"attachment-large size-large wp-image-260\" alt=\"Download veoza flashcard\" srcset=\"https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-of-veoza-flashcard.png 1020w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-of-veoza-flashcard-300x203.png 300w, https:\/\/info.e-med.co.il\/veoza\/files\/2024\/09\/moa-of-veoza-flashcard-768x520.png 768w\" sizes=\"(max-width: 1020px) 100vw, 1020px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-bd223d9\" data-id=\"bd223d9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2d47266 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"2d47266\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">RESOURCE<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b67fa47 elementor-widget elementor-widget-heading\" data-id=\"b67fa47\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Share the first-in-class MOA of VEOZA<sup>1,3<\/sup><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-234d937 elementor-widget elementor-widget-heading\" data-id=\"234d937\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Quickly reference VEOZA in your practice.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c625b6a elementor-tablet-align-justify elementor-align-right elementor-widget elementor-widget-button\" data-id=\"c625b6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"https:\/\/info.e-med.co.il\/protected\/veoza\/Veoza_flashcard.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download flashcard<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-84b40ef elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"84b40ef\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cc33f59\" data-id=\"cc33f59\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7b26f46 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7b26f46\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6ab90d4\" data-id=\"6ab90d4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd3c1c7 elementor-widget elementor-widget-heading\" data-id=\"fd3c1c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Discover efficacy and safety in VEOZA clinical trials<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-04c824e elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"04c824e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"\/veoza\/efficacy-and-safety\/\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-arrow-right\"><\/i>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b0b26a5 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"b0b26a5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29dfa8e\" data-id=\"29dfa8e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e14292f elementor-widget elementor-widget-text-editor\" data-id=\"e14292f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>REFERENCES<\/b>:\u00a0<b>1<\/b>. VEOZA <a href=\"\/veoza\/files\/2024\/09\/veoza-fezolinetant-smpc.pdf\" target=\"_blank\" rel=\"noopener\">[Veoza Israeli SmPC]<\/a>\u00a0<b>2<\/b>. Thurston RC. Vasomotor symptoms. In: Crandall CJ, Bachman GA, Faubion SS, et al., eds. Menopause Practice: A Clinician\u2019s Guide. 6th ed. Pepper Pike, OH: The North American Menopause Society, 2019:43-55.\u00a0<b>3<\/b>. Depypere H, Lademacher C, Siddiqui E, Fraser GL. Fezolinetant in the treatment of vasomotor symptoms associated with menopause. Expert Opin Investig Drugs 2021;30(7):681-94.\u00a0<b>4<\/b>. Jayasena CN, Comninos AN, Stefanopoulou E, et al. Neurokinin B administration induces hot flushes in women. Sci Rep (Epub) 02-16-2015.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>VEOZA is not a hormone. It\u2019s a first-in-class selective NK3 receptor antagonist that directly blocks NKB, a known trigger of VMS, from binding on the KNDy neuron1,3,4 KNDy: kisspeptin\/neurokinin B\/dynorphin, NK3: neurokinin 3, NKB: neurokinin B. Watch the MOA of VEOZA Homeostasis KNDy neurons in the hypothalamus are inhibited by oestrogen and stimulated by the [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-186","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.9 - aioseo.com -->\n\t<meta name=\"description\" content=\"VEOZA is not a hormone. It\u2019s a first-in-class selective NK3 receptor antagonist that directly blocks NKB, a known trigger of VMS, from binding on the KNDy neuron1,3,4 KNDy: kisspeptin\/neurokinin B\/dynorphin, NK3: neurokinin 3, NKB: neurokinin B. 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