Abstract
Purpose. To evaluate the efficacy of a new lubricant eye drop containing polyethylene glycol 400 and propylene glycol demulcents with hydroxypropyl-guar as a gelling agent (Test Product) to a system with carboxymethylcellulose (Control Product) for reducing dry eye signs and symptoms. Methods. Eighty-seven dry eye volunteers were enrolled at seven sites for this six-week, concurrently controlled, double-masked clinical study. Results. The Test Product significantly reduced conjunctival staining (p = 0.025) and temporal corneal staining (p = 0.024) compared to the Control. The Test Product also significantly reduced symptoms of dryness in the morning and evening, compared to the Control (p = 0.015 and p = 0.023, respectively). Subjects in the Test treatment group reported lower frequencies of foreign body sensation and felt their eyes were “refreshed longer” compared to those in the Control group (p = 0.033 and p = 0.037, respectively). Conclusions. The Test Product was more effective at reducing both the signs and symptoms of dry eye compared to the carboxymethylcellulose containing Control.
Mike T. Christensen, Steven Cohen, John Rinehart, Frank Akers, Bart Pemberton, Marc Bloomenstein, Mark Lesher, David Kaplan, David Meadows, Patricia Meuse, Charles Hearn & Jerry M. Stein
(2004) Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye, Current Eye Research, 28:1, 55-62, DOI: 10.1076/
ceyr.28.1.55.23495
https://doi.org/10.1076/ceyr.28.1.55.23495