Subject: Bioavalability in rat model – Osteoporosis

Study Name: Solubility and Bioavailability of Stabilized Amorphous Calcium Carbonate

Animal Population: Fifty-one 2-month-old male Wistar rats

Results: Calcium serum analysis revealed that calcium absorption from

ACC and ACC-C preparations was up to 40% higher than from CCC, whereas retention of ACC and ACC-C was up to 26.5% higher than CCC. Absorbed calcium in the femurs of ACC-administrated rats was 30% higher than in CCC-treated animals, whereas 15% more calcium  was absorbed following ACC-C treatment than following CCC treatment.  This study demonstrates the enhanced solubility and bioavailability of ACC over CCC. The use of stable ACC as a highly bioavailable dietary source for calcium is proposed based on the findings of this study.