{"id":3697,"date":"2013-01-14T15:47:59","date_gmt":"2013-01-14T13:47:59","guid":{"rendered":"http:\/\/info.e-med.co.il\/cerebonin\/?p=3697"},"modified":"2021-02-21T17:29:40","modified_gmt":"2021-02-21T15:29:40","slug":"ginkgo-biloba-extract-and-long-term-cognitive-decline-a-20-year-follow-up-population-based-study","status":"publish","type":"post","link":"https:\/\/info.e-med.co.il\/cerebonin\/ginkgo-biloba-extract-and-long-term-cognitive-decline-a-20-year-follow-up-population-based-study\/","title":{"rendered":"Ginkgo Biloba Extract and Long-Term Cognitive Decline: A 20-Year Follow-Up Population-Based Study"},"content":{"rendered":"<p dir=\"ltr\">H\u00e9l\u00e8ne Amieva<sup>1,2*<\/sup>, C\u00e9line Meillon<sup>1<\/sup>, Catherine Helmer<sup>1<\/sup>, Pascale Barberger-Gateau<sup>1<\/sup>, Jean\u00a0Francois Dartigues<sup>1<\/sup><\/p>\n<p dir=\"ltr\"><strong>PLOS ONE | www.plosone.org 1 January 2013 | Volume 8 | Issue 1 | e52755<\/strong><\/p>\n<hr \/>\n<p>\u05de\u05d7\u05e7\u05e8 \u05d6\u05d4 \u05e0\u05e2\u05e8\u05da \u05d1\u05de\u05d8\u05e8\u05d4 \u05dc\u05d4\u05e2\u05e8\u05d9\u05da \u05d0\u05ea \u05d9\u05e2\u05d9\u05dc\u05d5\u05ea \u05d5\u05d1\u05d8\u05d9\u05d7\u05d5\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1\u05ea\u05e8\u05d5\u05e4\u05d4 \u05e6\u05e8\u05d1\u05d5\u05e0\u05d9\u05df (<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span>) \u05e2\u05dc \u05d4\u05ea\u05e4\u05e7\u05d5\u05d3 \u05d4\u05e7\u05d5\u05d2\u05e0\u05d9\u05d8\u05d9\u05d1\u05d9 \u05d1\u05d2\u05d9\u05dc \u05d4\u05de\u05d1\u05d5\u05d2\u05e8 <strong>\u05dc\u05d0\u05d5\u05e8\u05da \u05d6\u05de\u05df.<\/strong><\/p>\n<p>\u05d1\u05de\u05d7\u05e7\u05e8 \u05e4\u05e8\u05d5\u05e1\u05e4\u05e7\u05d8\u05d9\u05d1\u05d9 \u05d6\u05d4 \u05e2\u05e7\u05d1\u05d5 <strong>\u05d1\u05de\u05e9\u05da 20 \u05e9\u05e0\u05d4<\/strong> \u05d0\u05d7\u05e8 3,612 \u05de\u05d1\u05d5\u05d2\u05e8\u05d9\u05dd \u05d1\u05e8\u05d9\u05d0\u05d9\u05dd (\u05e9\u05d0\u05d9\u05e0\u05dd \u05d3\u05de\u05e0\u05d8\u05d9\u05d9\u05dd) \u05d1\u05d2\u05d9\u05dc\u05d0\u05d9 65 \u05d5\u05de\u05e2\u05dc\u05d4.<\/p>\n<p><u>\u05de\u05ea\u05d5\u05db\u05dd<\/u>:<\/p>\n<ul>\n<li>589 \u05d3\u05d9\u05d5\u05d5\u05d7\u05d5 \u05e9\u05d4\u05e9\u05ea\u05de\u05e9\u05d5 \u05d1-<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span>, \u05dc\u05e4\u05d7\u05d5\u05ea \u05d1\u05d0\u05d7\u05d3 \u05de\u05ea\u05d5\u05da 10 \u05d1\u05d9\u05e7\u05d5\u05e8\u05d9 \u05d4\u05d4\u05e2\u05e8\u05db\u05d4 \u05e9\u05d1\u05d5\u05e6\u05e2\u05d5.<\/li>\n<li>149 \u05d3\u05d9\u05d5\u05d5\u05d7\u05d5 \u05e9\u05d4\u05e9\u05ea\u05de\u05e9\u05d5 \u05d1-piracetam \u05d1\u05d0\u05d7\u05d3 \u05de\u05d1\u05d9\u05e7\u05d5\u05e8\u05d9 \u05d4\u05d4\u05e2\u05e8\u05db\u05d4<\/li>\n<li>2,874 \u05dc\u05d0 \u05d3\u05d9\u05d5\u05d5\u05d7\u05d5 \u05e2\u05dc \u05e9\u05d9\u05de\u05d5\u05e9 \u05d1-<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d0\u05d5 \u05d1- piracetam<\/li>\n<\/ul>\n<p><strong><br \/>\n\u05d1\u05de\u05e9\u05da 20 \u05e9\u05e0\u05d4 \u05e2\u05e7\u05d1\u05d5 \u05d0\u05d7\u05e8 \u05e9\u05d9\u05e0\u05d5\u05d9\u05d9\u05dd \u05d1<\/strong>:<\/p>\n<ul>\n<li>\u05e6\u05d9\u05d5\u05df \u05de\u05d1\u05d7\u05df \u05d4\u05de\u05d9\u05e0\u05d9\u05de\u05e0\u05d8\u05dc (MMSE)<\/li>\n<li>\u05e9\u05d8\u05e3 \u05d4\u05d3\u05d9\u05d1\u05d5\u05e8<\/li>\n<li>\u05d6\u05d9\u05db\u05e8\u05d5\u05df \u05d7\u05d6\u05d5\u05ea\u05d9<\/li>\n<\/ul>\n<p>\u05d4\u05e0\u05ea\u05d5\u05e0\u05d9\u05dd \u05e9\u05e0\u05d0\u05e1\u05e4\u05d5 \u05e0\u05d5\u05ea\u05d7\u05d5 \u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea \u05de\u05d5\u05d3\u05dc Multivariate mixed linear effects.<\/p>\n<h3><strong>\u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05d4\u05de\u05d7\u05e7\u05e8: <\/strong><\/h3>\n<p><strong>\u05d1\u05de\u05d1\u05d7\u05df \u05d4\u05de\u05d9\u05e0\u05d9\u05de\u05e0\u05d8\u05dc<\/strong> \u05e0\u05de\u05e6\u05d0 \u05d4\u05d1\u05d3\u05dc \u05de\u05e9\u05de\u05e2\u05d5\u05ea\u05d9 \u05d1\u05d9\u05df \u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05e9\u05e0\u05d8\u05dc\u05d4\u00a0<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d0\u05d5 &#8211; piracetam \u05d1\u05d4\u05e9\u05d5\u05d5\u05d0\u05d4 \u05dc\u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05e9\u05dc\u05d0 \u05e0\u05d8\u05dc\u05d5 \u05d0\u05e3 \u05dc\u05d0 \u05d0\u05d7\u05d3 \u05de\u05e9\u05e0\u05d9 \u05ea\u05db\u05e9\u05d9\u05e8\u05d9\u05dd \u05d0\u05dc\u05d5.<\/p>\n<p><u>\u05d4\u05d4\u05e9\u05e4\u05e2\u05d4 \u05d4\u05d9\u05d9\u05ea\u05d4 \u05d1\u05db\u05d9\u05d5\u05d5\u05e0\u05d9\u05dd \u05de\u05e0\u05d5\u05d2\u05d3\u05d9\u05dd<\/u>: \u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05e9\u05e0\u05d8\u05dc\u05d5 <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d4\u05d9\u05d3\u05e8\u05d3\u05e8\u05d5 \u05dc\u05d0\u05d8 \u05d9\u05d5\u05ea\u05e8 \u05dc\u05e2\u05d5\u05de\u05ea \u05d0\u05dc\u05d4 \u05e9\u05dc\u05d0 \u05d8\u05d5\u05e4\u05dc\u05d5 \u05db\u05dc\u05dc. \u05dc\u05e2\u05d5\u05de\u05ea \u05d6\u05d0\u05ea, \u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05e9\u05d8\u05d5\u05e4\u05dc\u05d5 \u05d1-piracetam \u05d4\u05d9\u05d3\u05e8\u05d3\u05e8\u05d5 \u05de\u05d4\u05e8 \u05d9\u05d5\u05ea\u05e8 \u05d1\u05d4\u05e9\u05d5\u05d5\u05d0\u05d4 \u05dc\u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05dc\u05d0-\u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd (\u03b2= -0.6)<\/p>\n<p><strong>\u05d1\u05de\u05d1\u05d7\u05e0\u05d9 \u05e9\u05d8\u05e3 \u05d4\u05d3\u05d9\u05d1\u05d5\u05e8 \u05d5\u05d4\u05d6\u05d9\u05db\u05e8\u05d5\u05df \u05d4\u05d7\u05d6\u05d5\u05ea\u05d9<\/strong>:<\/p>\n<p>\u05dc\u05d0 \u05e0\u05e6\u05e4\u05d4 \u05d4\u05d1\u05d3\u05dc \u05d1\u05d9\u05df \u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05e0\u05d7\u05e7\u05e8\u05d9\u05dd \u05e9\u05e0\u05d8\u05dc\u05d4 <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05dc\u05d1\u05d9\u05df \u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05dc\u05d0-\u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd (\u03b2= 0.21 \u00a0\u05d5-\u03b2= -0.03 \u00a0\u05d1\u05d4\u05ea\u05d0\u05de\u05d4)<\/p>\n<p>\u05d1\u05e2\u05d5\u05d3 \u05e9\u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05e0\u05d7\u05e7\u05e8\u05d9\u05dd \u05e9\u05e0\u05d8\u05dc\u05d4 piracetam \u05d4\u05d9\u05d3\u05e8\u05d3\u05e8\u05d4 \u05de\u05d4\u05e8 \u05d9\u05d5\u05ea\u05e8 (\u03b2= -1.40 \u05d5- \u03b2= -0.44 \u00a0\u05d1\u05d4\u05ea\u05d0\u05de\u05d4).<\/p>\n<p><strong>\u05db\u05d0\u05e9\u05e8 \u05d4\u05e9\u05d5\u05d5 \u05d1\u05d0\u05d5\u05e4\u05df \u05d9\u05e9\u05d9\u05e8 \u05d1\u05d9\u05df \u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1 <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05dc\u05d1\u05d9\u05df \u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1 \u2013 piracetam<\/strong>, \u05e0\u05e6\u05e4\u05ea\u05d4 \u05d9\u05e8\u05d9\u05d3\u05d4 \u05d1-3 \u05d4\u05de\u05d1\u05d7\u05e0\u05d9\u05dd (\u03b2= -1.07 ,\u03b2= -1.61 \u00a0,\u03b2= -0.41 \u00a0\u05d1\u05d4\u05ea\u05d0\u05de\u05d4)<\/p>\n<h3><strong>\u05de\u05e1\u05e7\u05e0\u05d4<\/strong>:<\/h3>\n<p><u>\u05d1\u05d0\u05d5\u05db\u05dc\u05d5\u05e1\u05d9\u05d9\u05ea \u05de\u05d1\u05d5\u05d2\u05e8\u05d9\u05dd \u05d1\u05e8\u05d9\u05d0\u05d9\u05dd<\/u>: \u00a0\u05d0\u05dc\u05d5 \u05e9\u05e0\u05d8\u05dc\u05d5 <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d7\u05d5\u05d5 \u05d9\u05e8\u05d9\u05d3\u05d4 \u05e7\u05d5\u05d2\u05e0\u05d9\u05d8\u05d9\u05d1\u05d9\u05ea \u05de\u05ea\u05d5\u05e0\u05d4 \u05d9\u05d5\u05ea\u05e8 \u05de\u05d0\u05dc\u05d5 \u05e9\u05dc\u05d0 \u05e0\u05d8\u05dc\u05d5 \u05d0\u05ea \u05d4\u05ea\u05e8\u05d5\u05e4\u05d4. \u05d4\u05e9\u05e4\u05e2\u05d4 \u05d6\u05d5 \u05d9\u05d9\u05d7\u05d5\u05d3\u05d9\u05ea \u05dc- <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u00a0\u05de\u05d0\u05d7\u05e8 \u05d5\u05dc\u05d0 \u05e0\u05e6\u05e4\u05ea\u05d4 \u05d1\u05e7\u05e8\u05d1 \u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05e9\u05e0\u05d8\u05dc\u05d5 piracetam \u05d4\u05e9\u05d9\u05d9\u05db\u05ea \u05dc\u05e7\u05d1\u05d5\u05e6\u05ea \u05d4-nootropics.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u05e7\u05d9\u05e9\u05d5\u05e8 \u05dc\u05de\u05d0\u05de\u05e8:<\/strong><\/p>\n<p dir=\"ltr\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3543404\/pdf\/pone.0052755.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Amieva et al. PLOS ONE | www.plosone.org 1 January 2013 | Volume 8 | Issue 1 | e52755<\/a><\/p>\n<p class=\"ref\" dir=\"ltr\">For complete prescribing information please refer to Cerebonin\u00ae 120mg &#8211;<br \/>\nPhysician prescribing information approved by the Ministry of Health on March 2016<\/p>\n<p class=\"ref\" dir=\"ltr\" style=\"font-size: 9px;\">Cerebonin_Amieva_tsv_0121<\/p>\n","protected":false},"excerpt":{"rendered":"<p dir=\"ltr\">PLOS ONE | www.plosone.org<\/p>\n","protected":false},"author":2,"featured_media":3699,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"footnotes":""},"categories":[28,25,24],"tags":[],"class_list":["post-3697","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-article-en","category-cognitive-decline-updates","category-updates-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.9 - aioseo.com -->\n\t<meta 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