{"id":3685,"date":"2014-10-14T13:39:53","date_gmt":"2014-10-14T10:39:53","guid":{"rendered":"http:\/\/info.e-med.co.il\/cerebonin\/?p=3685"},"modified":"2021-02-21T17:25:10","modified_gmt":"2021-02-21T15:25:10","slug":"efficacy-and-safety-of-ginkgo-biloba-extract-egb-761-in-mild-cognitive-impairment-with-neuropsychiatric-symptoms-a-randomized-placebo-controlled-double-blind-multicenter-trial","status":"publish","type":"post","link":"https:\/\/info.e-med.co.il\/cerebonin\/efficacy-and-safety-of-ginkgo-biloba-extract-egb-761-in-mild-cognitive-impairment-with-neuropsychiatric-symptoms-a-randomized-placebo-controlled-double-blind-multicenter-trial\/","title":{"rendered":"Efficacy and safety of Ginkgo biloba extract EGb 761<sup>\u00ae<\/sup> in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multicenter trial"},"content":{"rendered":"<p dir=\"ltr\">Research Article<\/p>\n<p dir=\"ltr\">I. Gavrilova<sup>1<\/sup>, U.W. Preuss<sup>2<\/sup>, J.W. M. Wong<sup>2<\/sup>, R. Hoerr<sup>3<\/sup>, R. Kaschel<sup>4<\/sup>, N. Bachinskaya<sup>5<\/sup> and the GIMCIPlus Study<\/p>\n<div class=\"ref\">\n<p dir=\"ltr\">Group<sup>\u2020<\/sup><br \/>\n1. Mental Health Research Center of the Russian Academy of Medical Sciences, Moscow, Russia<br \/>\n2. Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital Prignitz, Perleberg, Germany<br \/>\n3. Clinical Research Department, Dr. Willmar Schwabe GmbH &amp; Co. KG, Karlsruhe, Germany<br \/>\n4. Department of Psychology, University of Osnabr\u00fcck, Osnabr\u00fcck, Germany<br \/>\n5. Institute of Gerontology, Academy of Medical Sciences, Kiev, Ukraine<\/p>\n<\/div>\n<hr \/>\n<p>\u05d4\u05de\u05d7\u05e7\u05e8 \u05e0\u05e2\u05e8\u05da \u05d1\u05de\u05d8\u05e8\u05d4 \u05dc\u05d4\u05e2\u05e8\u05d9\u05da \u05d0\u05ea \u05d9\u05e2\u05d9\u05dc\u05d5\u05ea \u05d5\u05d1\u05d8\u05d9\u05d7\u05d5\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1\u05ea\u05de\u05e6\u05d9\u05ea \u05d2\u05d9\u05e0\u05e7\u05d5 \u05d1\u05d9\u05dc\u05d5\u05d1\u05d4 \u05de\u05e1\u05d5\u05d2 <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05e2\u05dc \u05ea\u05e4\u05e7\u05d5\u05d3 \u05e7\u05d5\u05d2\u05e0\u05d9\u05d8\u05d9\u05d1\u05d9 \u05d1\u05d7\u05d5\u05dc\u05d9\u05dd \u05e2\u05dd \u05d9\u05e8\u05d9\u05d3\u05d4 \u05e7\u05d5\u05d2\u05e0\u05d9\u05d8\u05d9\u05d1\u05d9\u05ea \u05e7\u05dc\u05d4 (MCI ) \u05d4\u05de\u05dc\u05d5\u05d5\u05d4 \u05d1\u05ea\u05e1\u05de\u05d9\u05e0\u05d9\u05dd \u05d4\u05ea\u05e0\u05d4\u05d2\u05d5\u05ea\u05d9\u05d9\u05dd.<\/p>\n<p>\u05d1\u05de\u05d7\u05e7\u05e8 \u05d4\u05d5\u05db\u05dc\u05dc\u05d5 160 \u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05d4\u05de\u05d0\u05d5\u05d1\u05d7\u05e0\u05d9\u05dd \u05e2\u05dd MCI \u05d5\u05ea\u05e1\u05de\u05d9\u05e0\u05d9\u05dd \u05d4\u05ea\u05e0\u05d4\u05d2\u05d5\u05ea\u05d9\u05d9\u05dd. \u05d4\u05de\u05d7\u05e7\u05e8 \u05d4\u05d9\u05d4 \u05e8\u05d1- \u05de\u05e8\u05db\u05d6\u05d9, \u05db\u05e4\u05d5\u05dc \u05e1\u05de\u05d9\u05d5\u05ea \u05d5\u05d1\u05d4\u05e9\u05d5\u05d5\u05d0\u05d4 \u05dc\u05e4\u05dc\u05e1\u05d1\u05d5. \u05d4\u05e0\u05d1\u05d3\u05e7\u05d9\u05dd \u05d8\u05d5\u05e4\u05dc\u05d5 \u05d1- <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d1\u05de\u05d9\u05e0\u05d5\u05df 240 \u05de&quot;\u05d2 \u05dc\u05d9\u05d5\u05dd \u05d0\u05d5 \u05d1\u05e4\u05dc\u05e1\u05d1\u05d5, \u05d1\u05de\u05e9\u05da 24 \u05e9\u05d1\u05d5\u05e2\u05d5\u05ea.<\/p>\n<p><strong>\u05d4\u05e9\u05e4\u05e2\u05d5\u05ea <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d1\u05d4\u05d9\u05d1\u05d8 \u05d4\u05e7\u05d5\u05d2\u05e0\u05d9\u05d8\u05d9\u05d1\u05d9 \u05d4\u05d5\u05e2\u05e8\u05db\u05d5 \u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea<\/strong>:<\/p>\n<ul>\n<li>Trail making test (A\/B)<\/li>\n<li>Global ratings of change<\/li>\n<\/ul>\n<p><strong>\u05d4\u05e9\u05e4\u05e2\u05d5\u05ea <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d1\u05d4\u05d9\u05d1\u05d8 \u05d4\u05d4\u05ea\u05e0\u05d4\u05d2\u05d5\u05ea\u05d9<\/strong> <strong>\u05d4\u05d5\u05e2\u05e8\u05db\u05d5 \u05d1\u05d0\u05de\u05e6\u05e2\u05d5\u05ea<\/strong>:<\/p>\n<ul>\n<li>\u05de\u05d3\u05d3 NPI<\/li>\n<li>State-Trait Anxiety Inventory<\/li>\n<li>Geriatric Depression Scale<\/li>\n<\/ul>\n<h3><strong>\u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05d4\u05de\u05d7\u05e7\u05e8:<\/strong><\/h3>\n<ul>\n<li><strong>\u05d1\u05d4\u05d9\u05d1\u05d8 \u05d4\u05e7\u05d5\u05d2\u05e0\u05d9\u05d8\u05d9\u05d1\u05d9<\/strong>:<br \/>\n\u05e2\u05dc \u05e4\u05d9 \u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05e9\u05e0\u05d9 \u05de\u05d1\u05d7\u05e0\u05d9 \u05d4-Trail making test, \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1- <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05e0\u05de\u05e6\u05d0 \u05d8\u05d5\u05d1 \u05d9\u05d5\u05ea\u05e8 \u05de\u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1\u05e4\u05dc\u05e1\u05d1\u05d5.<\/li>\n<\/ul>\n<ul>\n<li><strong>\u05d1\u05d4\u05d9\u05d1\u05d8 \u05d4\u05d4\u05ea\u05e0\u05d4\u05d2\u05d5\u05ea\u05d9<\/strong>:\n<ul>\n<li>NPI composite score \u05dc\u05d4\u05e2\u05e8\u05db\u05ea \u05ea\u05e1\u05de\u05d9\u05e0\u05d9\u05dd \u05d4\u05ea\u05e0\u05d4\u05d2\u05d5\u05ea\u05d9\u05d9\u05dd, \u05e4\u05d7\u05ea \u05d1-7 \u05e0\u05e7\u05d5\u05d3\u05d5\u05ea \u05d1\u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1-<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> (p = 0.001)<\/li>\n<li>\u05e9\u05d9\u05e4\u05d5\u05e8 \u05e9\u05dc 4 \u05e0\u05e7\u05d5\u05d3\u05d5\u05ea \u05dc\u05e4\u05d7\u05d5\u05ea \u05d1-NPI, \u05e0\u05e6\u05e4\u05d4 \u05d1\u05e7\u05e8\u05d1 78.8% \u05de\u05d4\u05d7\u05d5\u05dc\u05d9\u05dd \u05e9\u05d8\u05d5\u05e4\u05dc\u05d5 \u05d1\u2013 <span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span>, \u05dc\u05e2\u05d5\u05de\u05ea 55.7% \u05de\u05d4\u05d7\u05d5\u05dc\u05d9\u05dd \u05e9\u05d8\u05d5\u05e4\u05dc\u05d5 \u05d1\u05e4\u05dc\u05e1\u05d1\u05d5 (<em>p<\/em> = 0.002)<\/li>\n<li>\u05e2\u05dc\u05d9\u05d5\u05e0\u05d5\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1-<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span> \u05d1\u05d4\u05e9\u05d5\u05d5\u05d0\u05d4 \u05dc\u05e4\u05dc\u05e1\u05d1\u05d5 \u05e0\u05de\u05e6\u05d0\u05d4 \u05d2\u05dd \u05d1\u05de\u05d3\u05d3 \u05d4-State-Trait Anxiety Inventory.<\/li>\n<li>\u05d1\u05e1\u05d5\u05dc\u05dd Geriatric depression \u05d4\u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05d4\u05d9\u05d5 \u05dc\u05d8\u05d5\u05d1\u05ea \u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1-<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span>.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li><strong>\u05d1\u05d4\u05d9\u05d1\u05d8 \u05d4\u05d1\u05d8\u05d9\u05d7\u05d5\u05ea\u05d9<\/strong>:<br \/>\n\u05ea\u05d5\u05e4\u05e2\u05d5\u05ea \u05d4\u05dc\u05d5\u05d5\u05d0\u05d9 \u05e9\u05e0\u05e6\u05e4\u05d5 \u05d1\u05de\u05d7\u05e7\u05e8 \u05d4\u05d9\u05d5 \u05db\u05d5\u05dc\u05df \u05dc\u05d0 \u05d7\u05de\u05d5\u05e8\u05d5\u05ea \u05d5\u05d3\u05d5\u05d5\u05d7\u05d5 \u05e2&quot;\u05d9 37 \u05d7\u05d5\u05dc\u05d9\u05dd \u05de\u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1-<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span>, \u05dc\u05e2\u05d5\u05de\u05ea 36 \u05d7\u05d5\u05dc\u05d9\u05dd \u05de\u05e7\u05d1\u05d5\u05e6\u05ea \u05d4\u05e4\u05dc\u05e1\u05d1\u05d5.<\/li>\n<\/ul>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-3744 size-full\" src=\"https:\/\/info.e-med.co.il\/cerebonin\/files\/2014\/10\/Gavrilova-2014.png\" alt=\"\" width=\"500\" height=\"389\" srcset=\"https:\/\/info.e-med.co.il\/cerebonin\/files\/2014\/10\/Gavrilova-2014.png 500w, https:\/\/info.e-med.co.il\/cerebonin\/files\/2014\/10\/Gavrilova-2014-300x233.png 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p class=\"ref\" dir=\"ltr\"><em>Int J Geriatr Psychiatry<\/em> 2014; <strong>29<\/strong>: 1087\u20131095<\/p>\n<h3><strong>\u05de\u05e1\u05e7\u05e0\u05d5\u05ea \u05d4\u05de\u05d7\u05e7\u05e8<\/strong>:<\/h3>\n<ul>\n<li>\u05e6\u05e8\u05d1\u05d5\u05e0\u05d9\u05df (<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span>) \u05de\u05e9\u05e4\u05e8\u05ea \u05d0\u05ea \u05d4\u05ea\u05e4\u05e7\u05d5\u05d3 \u05d4\u05e7\u05d5\u05d2\u05e0\u05d9\u05d8\u05d9\u05d1\u05d9 \u05d5\u05d4\u05d4\u05ea\u05e0\u05d4\u05d2\u05d5\u05ea\u05d9 \u05d1\u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05e2\u05dd MCI \u05d4\u05de\u05e6\u05d9\u05d2\u05d9\u05dd \u05d2\u05dd \u05ea\u05e1\u05de\u05d9\u05e0\u05d9\u05dd \u05d4\u05ea\u05e0\u05d4\u05d2\u05d5\u05ea\u05d9\u05d9\u05dd.<\/li>\n<li>\u05e6\u05e8\u05d1\u05d5\u05e0\u05d9\u05df (<span dir=\"ltr\">EGb 761<sup>\u00ae<\/sup><\/span>) \u05d4\u05d9\u05d0 \u05ea\u05e8\u05d5\u05e4\u05d4 \u05d1\u05d8\u05d5\u05d7\u05d4 \u05d5\u05e0\u05e1\u05d1\u05dc\u05ea \u05d4\u05d9\u05d8\u05d1.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>\u05e7\u05d9\u05e9\u05d5\u05e8 \u05dc\u05de\u05d0\u05de\u05e8:<\/strong><\/p>\n<p dir=\"ltr\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/gps.4103\">Gavrilova et al. Int J Geriatr Psychiatry 2014; 29: 1087\u20131095<br \/>\n<\/a><\/p>\n<p class=\"ref\" dir=\"ltr\">For complete prescribing information please refer to Cerebonin\u00ae 120mg &#8211;<br \/>\nPhysician prescribing information approved by the Ministry of Health on March 2016<\/p>\n<p class=\"ref\" dir=\"ltr\" style=\"font-size: 9px;\">Cerebonin_Gavrilova_tsv_0121<\/p>\n","protected":false},"excerpt":{"rendered":"<p dir=\"ltr\">Geriatric Psychiatry<\/p>\n","protected":false},"author":2,"featured_media":3686,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"footnotes":""},"categories":[28,25,24],"tags":[],"class_list":["post-3685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-article-en","category-cognitive-decline-updates","category-updates-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta 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