'מערכת אימד'Abstract
Gastrointestinal side-effects of alendronate (ALN) are believed to be associated with oesophageal lodging of tablets and perhaps reflux of gastric contents with alendronate under strongly acidic pH conditions. This leads to unfavourable posture restrictions when dosing.
L.A. Hodges, S.M. Connolly, J. Winter, T. Schmidt, H.N.E. Stevens, M. Hayward, C.G. Wilson,
Modulation of gastric pH by a buffered soluble effervescent formulation: A possible means of improving gastric tolerability of alendronate, International Journal of Pharmaceutics, Volume 432, Issues 1–2, 2012, Pages 57-62,
ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2012.04.073.
(https://www.sciencedirect.com/science/article/pii/S037851731200419X)